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| Sildenafil Citrate was the first significant oral treatment for male impotence filed with the US Food & Drug Administration (FDA) and the European Medicines Evaluation Agency. The FDA approved it for general use on March 27th 1998. It is now generally approved worldwide and is probably the most successful treatment for sexual dysfunction available to the world market. When a man is sexually aroused, the arteries in the penis relax and widen, allowing more blood to flow into the penis. As the arteries in the penis expand, the veins that normally carry blood away from the penis become compressed, restricting the blood flow out of the penis. With more blood flowing in and less flowing out, the penis enlarges, resulting in an erection. If the nerves or blood vessels associated with this process aren't working properly, a man may not be able to get an erection. Sildenafil Citrate increases blood flow to the penis, so that when a man is sexually aroused, he can get and keep an erection. Four out of five men with erectile dysfunction are able to respond to sexual stimulation with the assistance of this medication. Viagra is a phosphodiesterase 5 (PDE5) inhibitor. By inhibiting the PDE5 enzyme, which is found mainly in the penis, Viagra allows the chemical produced during sexual stimulation, cyclic GMP, to persist thereby enhancing the natural response to sexual stimulation by blocking the chemical that breaks down cyclic guanosine monophosphate (cGMP). This facilitates the relaxation of smooth muscle cells, thereby increasing blood flow to the penis resulting in the attainment and maintenance of an erection. Sexual stimulation or an amorous environment is generally a prerequisite and the results subside after a few hours. It is not a permanent cure and should be considered as a temporary and repeatable solution. |